Preheat your oven to 375°F (190°C).
In a large skillet, over medium heat, cook the ground beef or Italian sausage until browned. Drain excess fat, then stir in marinara sauce, garlic powder, onion powder, oregano, basil, salt, and black pepper. Let simmer for 5 minutes.
In a mixing bowl, combine ricotta cheese, a large egg, and a pinch of salt. Mix until smooth and creamy.
Spread a thin layer of meat sauce on the bottom of a 9x13 inch baking dish. Place three noodles over the sauce, spread half of the ricotta mixture, a third of the remaining meat sauce, and a third of the mozzarella cheese. Repeat layering.
Top with the last three noodles, remaining meat sauce, mozzarella cheese, and grated Parmesan cheese. Cover with aluminum foil and bake for 25 minutes. Remove foil and bake for an additional 15 minutes.
Let the lasagna cool for 10 minutes before slicing and serving.