Gather all your ingredients. Ensure your cooked chicken is shredded and your mixed vegetables are ready.
Bring a large pot of salted water to a boil. Add the egg noodles and cook according to package instructions, about 8.
In a large mixing bowl, combine the cream of chicken soup, sour cream, garlic powder, onion powder, salt, and pepper. Stir until well mixed.
Add the cooked egg noodles, shredded chicken, and frozen mixed vegetables to the creamy sauce. Gently fold until evenly coated.
Pour the mixture into a greased 9x13-inch baking dish. Spread evenly, sprinkle cheddar cheese on top, and add crushed potato chips if desired. Bake at 350°F for 30.